De-crumb your desktop model: Start by disconnecting your keyboard and mouse. Remove dust and debris by brushing the keys with a soft-bristled paintbrush or computer cleaning brush, or suck up the dirt with the brush hose attachments on the vacuum. You also can use compressed air to blow out small particles. To disinfect, pour a small amount of rubbing alcohol onto a clean rag and wipe down the keys and mouse. (Do not saturate the rag or keys). For deep crevices, use a cotton swab dipped in alcohol.
Tackle your laptop: Turn off the unit, and unplug and remove such items as a USB port hub and an external mouse; then follow the steps for desktop computers.
Clean: Once a month
Photo Credit: Flickr / Chris Bryson